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A new hope for couples with recurrent miscarriages!
After a miscarriage, expectant mothers are worried about ır would I encounter the same event again ”. Already one of 10 pregnancies is at risk. In some couples, this problem is repeated over and over again in subsequent pregnancies and the couple's hopes are broken. At this point, preimplantation genetic diagnosis which is a new treatment option can help us.
Recurrent abortion is defined as the occurrence of 3 or more consecutive pregnancy losses before the 20th gestational week. This problem affects 0.5-1% of couples. The problem can be caused by many different reasons. Genetic and hormonal disorders, reproductive organs such as structural deformities of the uterus, environmental factors and immune system disorders are among the main causes. Acıbadem Hospital Gynecology and DSpecialist and Reproductive Health Center Responsible Assoc. Dr. L. Cem Demirel He said: neden Genetic problems of the mother and father are 5% of all causes. Therefore, chromosome analysis of both men and women should be performed in couples with recurrent miscarriages. Recent data show that even if there is no chromosomal abnormality in couples with recurrent miscarriages, the embryos they produce have a higher rate of genetic abnormalities than expected. In other words, even if the couple is genetically healthy, embryos that will result in pregnancy often contain genetic disorders and therefore, even if pregnancy occurs, they do not continue in a healthy way and result in miscarriage. ”
Importance of genetic diagnosis in recurrent miscarriages
The rate of miscarriage is 11.5 percent after one miscarriage, 29.4 percent after two miscarriages, and 30-45 percent after three miscarriages. Statistics show that after each abortion, the likelihood of a new abortion increases markedly. In this case, if other factors that may cause miscarriage have been investigated and no cause has been found, either the couple must come across a genetically healthy embryo, or at the same time produce several embryos and find out which one is genetically healthy and transfer it to a healthy pregnancy. Need to obtain. This second option actually refers to the practice of in vitro fertilization and preimplantation genetic diagnosis. In vitro fertilization and preimplantation genetic diagnosis is effective not only in couples who cannot conceive, but also in couples who are pregnant and unable to achieve a healthy outcome. Assoc. Dr. Demirel touches on the importance of genetic diagnosis in recurrent miscarriages. it will both push the expectant mother into despair and pessimism and threaten her overall health. This is why we recommend in vitro fertilization in these couples to diagnose and provide treatment and achieve the birth of a healthy baby. Thus, we allow the development of eggs and embryos that develop after the fertilization of the eggs by taking one or two cell samples and select the genetically healthy ones are transferred to the expectant mother. We think that this approach is an effective approach both to reveal the cause of the couple's recurrent miscarriages and to treat this condition. ”
Genetic diagnosis increases IVF success rate
Another group of patients who used preimplantation genetic diagnosis was couples with repeated failed IVF trials. For this group of patients, preimplantation genetic diagnosis can be improved in the next IVF trial. Assoc. Dr. Demirel approaches the issue as follows: veril Our data show that more than expected chromosomal defects are found in the embryos of couples that failed in repeated in vitro fertilization trials. Therefore, before the embryos are delivered to the mother's womb in these pairs, the chance of pregnancy is increased when the genetically normal embryos are tested and placed in the mother's womb. Preimplantation genetic diagnosis will reveal the chromosomal abnormalities of the embryos and will lead to the selection of a healthy embryo and increase the chance of pregnancy. ”