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There's not enough data to completely rule out risk for most drugs in pregnancy (for safety reasons, few studies test drugs in human pregnancies), but I would rate anti-diarrhea drugs as low-risk.
In fact, you should use either a kaolin-and-pectin- (Kaopectate) or loperamide- (Imodium) type medication if you're having bad diarrhea, because otherwise you could become seriously dehydrated and put your baby at risk. If you get really dehydrated, your blood won't be able to circulate as well to your organs or your placenta, and you'll need to be hospitalized and given intravenous fluids.
If you have severe or bloody diarrhea, see your healthcare provider right away. An underlying bacterial cause, such as food poisoning, could pose a threat to both you and your baby.
By the way, it's always good to check all of the ingredients on the contents label, and call your doctor before taking any over-the-counter medicine, to make sure it's safe for you and your baby.